Molecular Cloning and Characterization of Marmoset Aldehyde Oxidase
نویسندگان
چکیده
منابع مشابه
Molecular Cloning and Characterization of Marmoset Aldehyde Oxidase.
Common marmosets (Callithrix jacchus), New World monkeys, are a promising primate model for preclinical drug metabolism studies because of the similarities of cytochrome P450 (P450) enzyme function to those of humans. Despite an increasing number of drug candidates catalyzed by non-P450 enzymes, drug metabolizing enzymes other than P450s have been hardly identified or characterized in marmosets...
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A reverse transcriptase-polymerase chain reaction experiment was done to synthesize a homologous polyphenol oxidase (PPO) probe from apricot (Prunus armeniaca var Bergeron) fruit. This probe was further used to isolate a full-length PPO cDNA, PA-PPO (accession no. AF020786), from an immature-green fruit cDNA library. PA-PPO is 2070 bp long and contains a single open reading frame encoding a PPO...
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Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan (SU, HY), Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Kainan, Wakayama, Japan (YU), Department of Applied Developmental Biology, Central Institute for Experimental Animals, Kawasaki, Japan (TI, ES), and Keio Advanced Research Center, Keio Un...
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A new member of the connexin gene family has been identified and designated rat connexin-3 1 (Cx3 1) based on its predicted molecular mass of 30,960 daltons. Cx31 is 270 amino acids long and is coded for by a single copy gene. It is expressed as a 1.7-kilobase mRNA that is detected in placenta, Harderian gland, skin, and eye. Cx31 is highly conserved and can be detected in species as distantly ...
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ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2017
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.117.076042